CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy
نویسندگان
چکیده
منابع مشابه
CD4(+)CD25(+) T cells facilitate the induction of T cell anergy.
T cell anergy is characterized by the inability of the T cell to produce IL-2 and proliferate. It is reversible by the addition of exogenous IL-2. A similar state of unresponsiveness is observed when the proliferative response of murine CD4(+)CD25(-) T cells is suppressed in vitro by coactivated CD4(+)CD25(+) T cells. We have developed a suppression system that uses beads coated with anti-CD3 a...
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T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective. Exposure to a tolerizing peptide Ag regimen instead induced aggressive CD4(+) cell cycle progression and increased Ag responsiveness (priming). Reconstitution of T cell-deficient mice by an adoptive transfer of mature peripheral lymphocytes was accompanied by the development of a CD25(+)Foxp3(+)CTLA-4(+)CD4(+)...
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While the "true" role of T cell anergy in promoting peripheral tolerance continues to be debated, it is clear that studying the various models of anergy have led to important insight in terms of understanding the pathways and molecules responsible for T cell activation and inhibition. This review will examine our current understanding of CD4+ T cell anergy. In particular, it will focus on the s...
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Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...
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PURPOSE Retinal pigmented epithelial (RPE) cells may contribute to retinal immune privilege. Daily phagocytosis and degradation of photoreceptor cell outer segment tips by RPE provide substantial amounts of retinal autoantigens for potential MHC occupancy. RPE are well placed to modulate antigen (Ag)-specific activation of T cells in the outer retina under conditions in which inflammatory media...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2001
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.167.8.4271